Author

Darren C. Johnson

Pfizer (United States)ORCID 0000-0002-0858-6152Unclaimed ORCID profile · follow to get notified of new preprints

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Darren C. Johnson1 paper

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Benedikt Bosbach· 1 shared Benjamin OrrisiD· 1 shared David J. ShieldsiD· 1 shared James T. StiversiD· 1 shared Kevin W. HuynhiD· 1 shared Min Woo SungiD· 1 shared Seungil HaniD· 1 shared Shridhar Bhat· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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9 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

Benedikt Bosbach

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1 paper

Recent·Most cited

BiochemistryNucleic Acids ResearchPeer-reviewedNov 1, 2023

Guanine-containing ssDNA and RNA induce dimeric and tetrameric SAMHD1 in cryo-EM and binding studies

Benjamin Orris, Min Woo Sung, Shridhar Bhat…·James T. Stivers

This study shows that guanine-containing ssDNA and RNA induce dimeric or tetrameric SAMHD1, with tetramers being inactive for dNTPase and RNase activity.

8 citations

cryo-EMexperimental assay

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