Duncan J. Smith

The paper maps helicase activity genome-wide using AID-mediated mutational footprints, revealing Hrq1's association with RNA polymerase III-transcribed genes.

The paper shows that AT/TA repeats form DNA structures that are processed by nucleases and repositioned to the nuclear periphery for repair.

This study shows that reducing DNA polymerase delta in yeast causes replication stress, genome instability, and reliance on repair pathways.

The paper investigates the role of DNA Polymerase α and Ctf4 in DNA replication initiation and lagging-strand priming in S. cerevisiae, showing distinct sensitivities to Ctf4 and Pol levels.

The study shows that tRNA gene replication fork pausing in yeast is not due to transcription but involves topoisomerases and Rad18 repair, even when transcription is blocked.

The paper investigates the roles of Rad27, Dna2, and Exo1 in processing Okazaki fragments in vivo, showing Rad27's primary role and the uncoupling of nuclease activity from DNA replication.

This study shows that DNA replication initiation and termination in human cells are coupled with transcription, with initiation near transcription start sites and termination at polyadenylation sites.

The paper investigates the roles of Pif1 and Rrm3 helicases in suppressing replication fork arrest at tRNA genes in yeast.