Stefan H. Mueller

This paper uses FCCS to quantify affinity, cooperativity, and kinetic stability in ternary protein complexes, showing cooperative stabilization of the HER2-trastuzumab-pertuzumab complex.

This study investigates how DNA supercoiling affects the activity of the restriction enzyme EcoRV at the single-molecule level using TIRF microscopy.

This paper introduces a DNA barcoding method to simultaneously profile kinetic properties of protein variants at the single-molecule level, revealing kinetic diversity and structural subpopulations.

This study optimizes nanobody-based quenchbodies for enhanced protein detection, achieving fluorescence increases of 1.5-2.4-fold and detecting IL-6 down to 2 nM.