Lucien E. Weiss

The paper investigates how membrane nanodomains influence constitutive activity of GPCRs, finding that A2AR is confined in nanodomains with Gas, promoting basal signaling.

The paper shows that protein agglomerates in E. coli regulate cytoplasmic rheology, with diffusion inversely correlating with amino acid metabolism protein abundance.

This paper introduces aTrack, a tool for classifying single-particle motion as Brownian, confined, or directed, and demonstrates its application in cellular and biosensing contexts.

This paper benchmarks the ExaTrack tool for analyzing single-molecule dynamics, focusing on its ability to handle complex motion types and transition kinetics using simulated data.

This paper introduces patch deconvolution to accelerate 3D cellular imaging in Fourier light-field microscopy, achieving faster reconstruction speeds without compromising quality.

This paper introduces ASA-PD, an imaging method to detect and map α-synuclein oligomers in Parkinson's disease brain tissue, revealing a specific subpopulation of nanoscale oligomers as an early hallmark of the disease.

The paper tracks DNA repair dynamics in yeast using high-throughput methods, revealing chromatin reconfiguration linked to single- and double-strand breaks.

The paper maps α-synuclein oligomers in Parkinson's disease brain tissue to identify aggregation-susceptible cells and proposes a population-level model for early pathology.

This paper introduces vortex light field microscopy, achieving 3D spectral single-molecule imaging with 25 nm spatial and 3 nm spectral precision.

The paper investigates the role of nuclear basket proteins in NPC distribution and mobility in budding yeast, showing their stable association and exclusion of NPCs from the nucleolar region.

RASP detects fluorescent puncta in complex cellular backgrounds with high precision and speed, outperforming existing methods by using image gradients to separate objects from noise.