Xiaoxian Li

This study compares immune cell deconvolution and cancer subtype gene signatures in TNBC, finding that immune aggregates better predict outcomes than subtype signatures.

This study identifies HELZ as an RNA-DNA helicase that resolves R loops to support homologous recombination repair and genomic stability.

This study uses spatial omics to identify distinct tumor microenvironment profiles in Black and White American TNBC patients, linking them to different immunosuppressive mechanisms and clinical outcomes.

This study identifies immune and stromal factors driving resistance to Trastuzumab Deruxtecan in HER2+ metastatic breast cancer using spatial proteomics.

The paper identifies spatial interactions between NOS2, COX2, and T-effector cells in ER- breast cancer, linking these patterns to poor patient outcomes and suggesting potential therapeutic strategies.

This study identifies NOS2 and COX2 as key spatial targets in ER- breast cancer that influence immune phenotypes and clinical outcomes through spatial analysis of tumor microenvironments.