Synthetic BiologybioRxivPreprint
Changing the initiation unit of nonribosomal peptide synthetases to access underexplored biosynthetic potential
Xianping Bai, Lin Zhong, Hanna Chen…·Xiaoying Bian
This paper introduces a strategy to activate silent NRPS biosynthetic gene clusters by swapping initiation units, successfully recovering three of six previously silent pathways and identifying five novel lipopeptides.
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