Richard E. Lenski

This paper reconstructs the genomic evolution of a Clostridium botulinum strain used for industrial botulinum neurotoxin production, identifying key mutations that drove its domestication and adaptation.

This study shows that during long-term bacterial adaptation, fitness effects of mutations become less severe, but pleiotropic effects in new environments become more severe, indicating trade-offs between robustness and fragility.

This study shows that simple sequence repeats in Bartonella bacteria drive adaptation to specific rodent hosts through frameshift mutations in adhesin genes.

The paper identifies 'adaptive momentum' as a dynamic where selective sweeps reduce purifying selection, allowing populations to explore fitness valleys and access new fitness peaks.

The paper analyzes 264 genomes from 12 Escherichia coli populations over 50,000 generations to study genome evolution dynamics and finds that most fixed mutations are beneficial, with neutral mutations accumulating at a constant rate.

This study tracks genetic evolution in Escherichia coli populations over 20,000 generations, revealing clonal interference, selective sweeps, and frequency-dependent interactions among mutations.

The paper develops a framework to measure frequency-dependent fitness in microbial populations with cross-feeding interactions using a Monod-type model and long-term evolution experiment data.