Molecular BiologyProceedings of the National Academy of SciencesPeer-reviewed
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Targeting Stem-loop 1 of the SARS-CoV-2 5'UTR to suppress viral translation and Nsp1 evasion
Setu M. Vora, Pietro Fontana, Tianyang Mao…·Hao Wu
SARS-CoV-2 5' UTR stem-loop 1 (SL1) lets reporters escape Nsp1 translational shutdown. LNA antisense oligos against SL1 restore Nsp1 suppression and reduce infected Vero E6 cells.