Hao Wu

This study reveals the structure of MyD88 and its oncogenic mutant, showing direct DNA binding and its role in innate immune responses.

This study identifies a therapeutic target, the entrapment complex, that clears toxic protein accumulation in distinct proteinopathies by disrupting a cargo receptor complex.

This study uses cryo-ET to visualize NLRP3 inflammasome condensates at the MTOC during activation, revealing structural changes and pyroptosis in macrophages.

This paper presents the cryo-EM structure of the Pacs1-Wdr37 complex, revealing its assembly mechanism and stability, and identifies a mutation linked to neurodevelopmental syndrome.

The paper shows that chronic exposure to oxidized phospholipids primes and activates NLRP3 via NRF2, independent of microbial cues, contributing to atherogenesis.

The paper shows that specific peptides inhibit Aβ aggregation and reduce cognitive impairment in Alzheimer's disease models.

The paper identifies calcium-driven lipid scrambling as the mechanism activating NINJ1-mediated plasma membrane rupture during lytic cell death.

This study shows that targeting liver epsins reduces atherosclerosis by preventing PCSK9-mediated LDLR degradation and improving LDL-C clearance.

SARS-CoV-2 5' UTR stem-loop 1 (SL1) lets reporters escape Nsp1 translational shutdown. LNA antisense oligos against SL1 restore Nsp1 suppression and reduce infected Vero E6 cells.