Author

Cuyler Luck

University of California, San FranciscoORCID 0000-0002-1150-0057Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Ross A. OkimotoiD· 3 shared Kyle A. JacobsiD· 2 shared Rovingaile Kriska PonceiD· 2 shared Christopher D. MacaraigiD· 1 shared Julia RiadiD· 1 shared Nicholas J. ThomasiD· 1 shared Nicole Shlimon· 1 shared Zeinab KosibatyiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 19 mutual co-author links

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3 shared papersCancer Biology

Ross A. OkimotoORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintMay 13, 2025

First Generation Tools for the Modeling of Capicua (CIC) - Family Fusion Oncoprotein-Driven Cancers

Cuyler Luck, Kyle A. Jacobs, Julia Riad…·Ross A. Okimoto

The paper develops synthetic CIC-family fusion oncoproteins to study their distinct transcriptional effects in cancer.

DOI 10.1101/2025.05.13.653825

humanexperimental assay

𝕏 PostBluesky

Cancer BiologyCancer Research CommunicationsPeer-reviewedNov 12, 2024

The Capicua C1 Domain is Required for Full Activity of the CIC::DUX4 Fusion Oncoprotein

Cuyler Luck, Kyle A. Jacobs, Ross A. Okimoto

This study shows that the C1 domain of CIC is required for full activity of the CIC::DUX4 fusion oncoprotein, highlighting the importance of breakpoint location in fusion function.

1 citation

humanexperimental assay

𝕏 PostBluesky

Cancer BiologybioRxivPreprintOct 11, 2023

Mapping chromatin state and transcriptional response in CIC-DUX4 undifferentiated round cell sarcoma

Nicholas J. Thomas, Cuyler Luck, Nicole Shlimon…·Ross A. Okimoto

This study identifies CIC-DUX4-mediated chromatin states and transcriptional responses in sarcoma using ChIP and RNA-Seq analysis of patient-derived cells.

5 citations

𝕏 PostBluesky