Author
University College DublinORCID 0000-0002-1257-359XUnclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Anthony M. Doherty, Eimear Lagan, Richard J. R. Elliott…·Gerard L. Brien
This study shows SS18-SSX sustains oncogenic transcription without needing SWI/SNF activity, identifies P300 as a critical co-factor, and demonstrates targeting P300 or SWI/SNF as therapeutic strategies.
Eimear Lagan, Dáire Gannon, Ademar Jesus Silva…·Gerard L. Brien
The paper identifies specific cPRC1 complexes, CBX4/PCGF4, that mediate oncogenic gene repression in DMG cells downstream of H3K27M mutation.
Camille Ternet, Philipp Junk, Thomas Sevrin…·Christina Kiel
The paper identifies context-specific KRAS-effectors in Caco-2 cells and shows that culture contexts have a larger impact on interaction rewiring than genetic contexts.