Philipp Junk

The paper uses cSTAR to analyze endothelial cell transcriptomic states under different flow conditions, identifies CDK2 as a key regulator of artery remodeling.

The paper predicts Ras-effector binding affinities using structural models and identifies mutations that alter binding energy, providing insights into rewiring Ras interactions.

The paper identifies context-specific KRAS-effectors in Caco-2 cells and shows that culture contexts have a larger impact on interaction rewiring than genetic contexts.