Author

Philippe Pelupessy

Centre National de la Recherche ScientifiqueORCID 0000-0002-1300-2692Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:imputation· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Duc-Duy VuiD· 2 shared Fabien FerrageiD· 2 shared Guillaume BouvigniesiD· 2 shared Jeremy M. StarkiD· 2 shared Ludovic CarlieriD· 2 shared Mauro ModestiiD· 2 shared Alessio BonucciiD· 1 shared Aliénor LahlouiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiophysics

Duc-Duy VuORCID

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3 papers

Recent·Most cited

BiochemistryJournal of the American Chemical SocietyPeer-reviewedAug 25, 2026

Kinetic and Mechanistic Characterization of RSpFAST, A Non-Covalent Versatile Chemogenetic Platform for Fluorescence Imaging

Yuriy Shpinov, Mrinal Mandal, Vincent M.L. Van Deuren…·Ludovic Jullien

This paper introduces RSpFAST, a non-covalent chemogenetic platform for fluorescence imaging, and demonstrates its dual behavior as a stable label and a reversible photoswitcher.

DOI 10.1021/jacs.6c08277

fluorescence / live-cell microscopyexperimental assay

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BiophysicsbioRxivPreprintJul 23, 2026

Molecular characterization of MRI/CYREN reveals the Ku binding mode and the role of multimerization in stimulating the activity of NHEJ in DNA repair

D. Vu, Kaela Makins, Sonja Knoedlstorfer…·Fabien Ferrage

This study characterizes MRI/CYREN's structure and function in NHEJ, showing its disordered regions bind Ku80 and multimerization enhances DNA repair efficiency.

DOI 10.64898/2026.07.22.740027

humanproteomics

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BiophysicsNature Structural & Molecular BiologyPeer-reviewedJun 19, 2024

Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust cellular NHEJ and drive the formation of ligation-boosting condensates in vitro

Duc-Duy Vu, Alessio Bonucci, Manon Brenière…·Fabien Ferrage

This study characterizes the multivalent interactions of XRCC4 and XLF CTRs, showing they form condensates that enhance DNA ligation in vitro and suggest roles in NHEJ dynamics and cancer biology.

24 citations

humanstructural biology

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