Robbert M. Spaapen

This study shows that SPPL3 in tumor cells affects innate immune responses by modulating nsGSLs, reducing susceptibility to neutrophils, NK cells, and γδ T cells.

This study shows that tumor-expressed nsGSLs impair OT-I T cell activation in vitro and promote tumor growth in vivo by evading immune responses.

This study isolates and expands pure γδ T cells from blood while maintaining their anti-tumor functions, showing effective expansion and effector activity.