Author

Corey H. Yu

The University of Texas at San Antonio Health Science CenterORCID 0000-0002-1374-4194Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Dmitri N. IvanoviD· 2 shared Anindita NayakiD· 1 shared Claudia McCowniD· 1 shared Daohong ZhouiD· 1 shared Digant NayakiD· 1 shared Dongwen LviD· 1 shared Pirouz Ebadi· 1 shared Shaun K. OlseniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

Dmitri N. IvanovORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintAug 20, 2025

Single-Assay Characterization of Ternary Complex Assembly and Activity in Targeted Protein Degradation

Corey H. Yu, Vi Dougherty, Dongwen Lv…·Dmitri N. Ivanov

This paper introduces a fluorescent assay to quantify ubiquitination kinetics in targeted protein degradation, enabling measurement of degrader and ligase affinities and ternary complex activity.

DOI 10.1101/2025.08.20.671298

proteomicsexperimental assay

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BiochemistryNature CommunicationsPeer-reviewedJan 17, 2025

Allosteric substrate activation of SAMHD1 shapes deoxynucleotide triphosphate imbalances by interconnecting the depletion and biosynthesis of different dNTPs

Claudia McCown, Corey H. Yu, Dmitri N. Ivanov

This study reveals how SAMHD1's allosteric activation regulates dNTP levels by linking depletion and biosynthesis, impacting HIV-1 replication and dNTP homeostasis.

16 citations

humanproteomics

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