GeneticsJournal of Molecular BiologyPeer-reviewed
High-Throughput Single-Molecule R-loop Footprinting Reveals Principles of R-loop Formation
Maika Malig, Stella R. Hartono, Jenna M. Giafaglione…·Frederic L. Chedin
The paper develops SMRF-seq to profile R-loops with high resolution and shows they form from unspliced transcripts at genic hotspots, influenced by DNA sequence and topology.