Tsuyoshi Yamada

This study shows that combining azole antifungals with different Cyp51 isozyme selectivities synergistically inhibits fungi with multiple Cyp51 isozymes.

This paper develops an efficient gene targeting system in Trichophyton rubrum using a Δku80 strain and shows that Cyp51A contributes to azole drug tolerance by responding to efinaconazole.

This study identifies Cdc42 and Rac GTPase inhibition as a strategy to block hyphal elongation and virulence in Trichophyton rubrum, with EHop-016 showing promise as an antifungal lead.

This study identifies the TrPtk2-TrPma1 pathway in Trichophyton rubrum as critical for terbinafine tolerance and suggests it as a target for antifungal therapy.