António Zorzano

This study shows that Anxa6-/- mice have impaired fasting-induced hepatic gluconeogenesis, leading to hypoglycaemia and reliance on lipid oxidation.

This study shows that mechanical confinement causes mitochondria to relocate to the nucleus, leading to a nuclear ATP surge that supports DNA repair and cell cycle progression.

This study maps the differentiation trajectory of iPSCs to hepatic stellate cells, identifying RORA as a key regulator of metabolic reprogramming and fibrosis.

This study shows that reduced Opa1 in endothelial cells of old mice worsens vascular function and increases kidney oxidative stress.

This study shows that Mfn2 in NAc D2-MSNs regulates social dominance and neuronal function, while D1-MSNs show transient effects on competitiveness.

This study shows that Slc7a7 deficiency in mice causes erythropoiesis failure and iron overload, with erythropoietin supplementation as a potential therapy for LPI.

The paper reanalyzes T2D GWAS data to identify a rare X chromosome variant associated with increased T2D risk in males.