Yuxuan Wang

The paper introduces SCIM, a method using information geometry to quantify cell phenotype transition manifolds by analyzing curvature and velocity in single-cell gene expression data.

The paper shows PARG inhibition causes nuclear condensates that sequester PAR-binding repair proteins, leading to cytotoxicity and identifying PAR-binding factor loss as potential biomarkers for PARG-targeted therapy.

This study identifies a potent PVC-dechlorinating activity in gut microbiota of insect larvae using comparative metagenomics.