Nicholas Thomas Perry

The paper identifies prokaryotic homologs of the major vault protein that assemble into vault nanocapsules, revealing structural and size variability.

The paper uses large language models to discover a novel family of reverse transcriptases with tandem repeat arrays from metagenomic data.

This paper describes the engineering of IS622 bridge recombinases to enable efficient and specific DNA rearrangements in the human genome, including insertion, inversion, and excision of up to 0.93 megabases.

The paper demonstrates that IS110 insertion sequences use a structured RNA to direct sequence-specific DNA recombination, enabling modular genome editing.

The paper demonstrates multi-input drug-controlled gene expression using engineered nuclear hormone receptors, showing tunable outputs with multiple drugs.