Cell BiologyeLifePeer-reviewed
Topological stress triggers persistent DNA lesions in ribosomal DNA with ensuing formation of PML-nucleolar compartment
Alexandra Urbancokova, Terezie Hornofova, Josef F. Novak…·Pavla Vašicová
This study shows that topological stress and RNAPI inhibition cause rDNA damage, leading to PML-nucleolar compartments (PNAs) that help prevent rDNA instability and may contribute to aging and cancer.
6 citations