Sivaraman Padavattan

This study shows that α-synuclein protofibrils induce tunneling nanotubes in astrocytes, promoting stemness and apoptosis resistance through pFAK-Nanog interaction and p53 degradation.

This study shows that tunneling nanotubes (TNTs) in astroglia maintain cytoskeleton tension and lamin integrity to counteract α-synuclein-induced senescence.

This study identifies how Parkinson's Disease-associated α-Synuclein interacts with histone dimers, revealing structural and functional insights into its role in chromatin regulation.

This study shows that α-synuclein protofibrils induce tunneling nanotube biogenesis in astrocytes, which facilitates clearance of toxic aggregates and reversal of cellular senescence, leading to enhanced proliferation.