GeneticsbioRxivPreprint
Pharmacological cAMP stimulation via prostaglandin receptors rescues ciliary defects in CEP290-deficient patient and mouse models
France de Malglaive, Iris Barny, Shahd Machroub…·Jean‐Philippe Annereau
This study shows that Taprenepag, a PGE2 receptor agonist, improves cilia formation and light sensitivity in CEP290-deficient models by stimulating cAMP synthesis.
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