Molecular BiologyCell chemical biologyPeer-reviewed
Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization
Martin P. Schwalm, Andreas Krämer, Anja Dölle…·Stefan Knapp
This paper develops cell-based assays to monitor PROTAC degradation kinetics and ternary complex formation, revealing that ternary complex stability is critical for PROTAC efficiency.
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