Arnold J. Levine

The paper identifies p53-hormone receptor regulatory grammars distributed by Alu elements in mammary and muscle cells, with implications for breast cancer and muscle aging.

This study compares genomic and immunologic features of germline TP53-driven breast cancers to sporadic breast cancers, finding distinct patterns of genomic instability and immune infiltration.

The paper analyzes how neoantigenic properties of TP53 variants correlate with cancer risk and presentation in Li-Fraumeni syndrome carriers.

The paper develops DNA methylation predictors for mammalian maximum lifespan, gestation time, and sexual maturity, showing species-level epigenetic signatures that differ from individual lifespan variation.

The paper analyzes two single-cell datasets to study how p21 and p53 dynamics influence cell cycle arrest and mitosis frequency after radiation exposure.