Marcus D. Wilson

This study identifies a novel N-terminal region in TET1 that binds nucleosomes, enabling chromatin association in mouse embryonic stem cells through structural and biochemical validation.

This study investigates the role of H2A.Z-H2B.V nucleosomes in transcription initiation in Trypanosoma brucei, revealing their unique structural and functional properties.

This study examines how mutations in the PWWP domain of DNMT3A affect chromatin recruitment through different mechanisms, leading to distinct disease phenotypes.

This study shows MeCP2 binds methylated DNA in nucleosomes via linker DNA interactions beyond its canonical methyl binding domain, revealing a new mechanism for chromatin DNA methylation recognition.

This study determines the structure of H3.V-H4.V nucleosomes in Trypanosoma brucei and shows how these variants promote nucleosome plasticity in repressed chromatin.

This study reveals how the chromosomal passenger complex (CPC) interacts with nucleosomes to protect centromeric chromatin, showing its non-catalytic role in maintaining chromatin stability.

This study determines the structure and function of KKT23, a kinetochore acetyltransferase in trypanosomes, showing it acetylates histone H2A and interacts with KKT22.

This study identifies the N-terminal region of DNMT3A as containing multiple chromatin-binding motifs that mediate recruitment through interactions with nucleosomes and ubiquitylated histone H2AK119.

This study shows that DNMT3B PWWP mutations cause hypermethylation of heterochromatin marked by H3K9me3, disrupting DNA methylation homeostasis and contributing to ICF syndrome, cancer, and aging.

This study investigates how the BRCA1-BARD1 complex interacts with chromatin containing specific histone modifications, showing it preferentially binds di-nucleosomes and uses multivalent interactions to overcome inhibitory marks.

This study identifies BARD1's role in recruiting BRCA1 to DNA damage sites via H2AK15ub binding, linking it to HR and pathway choice.