Thomas M. Wishart

This study identifies heterozygous lysosomal enzyme gene mutations as risk factors for Alzheimer's disease and validates their impact on amyloid-beta processing using mouse models.

This study shows that ABCC1 deficiency in male mice affects glucose metabolism and insulin tolerance on a high-fat diet without altering tissue corticosterone levels.

This study shows that inhibiting necroptosis in aged mice reduces axonal degeneration, neuroinflammation, and memory decline, promoting brain rejuvenation.

This study examines the effects of chronic CBD in a mouse model of neuroinflammation, neurodegeneration, and seizures, finding reduced astrocytosis and microgliosis but no impact on seizures or neuron survival.

The paper identifies over 5,500 synaptic proteins in Alzheimer’s disease and controls, revealing APOE4-associated changes in synaptic and mitochondrial function and neuroimmune signaling.