Vladimir Denic

This study identifies Retro-1 and Retro-2 as inhibitors that trap Get3, blocking tail-anchored protein biogenesis by stabilizing a stalled complex.

The paper identifies Ypl225w as a chaperone that facilitates GTP-driven co-translational folding of eEF1A by interacting with the ribosome and NAC.

The paper shows that the yeast exportomer complex inhibits Atg36 phosphorylation to prevent pexophagy, revealing a mechanism linking organelle biogenesis to autophagy regulation.