Fatima Kamal Zaidi

This study shows multi-component biomolecular condensates suppress amyloid formation by sequestering proteins, limiting their availability for fibril formation.

The paper shows that separable interactions in A1-LCD allow tunable metastability of condensates, which can suppress amyloid fibril formation even with ALS mutations.

The paper develops a machine learning model to predict phase separation propensities of disordered proteins from sequence, identifying 5% of human IDRs likely to undergo homotypic phase separation.