Integration of Alzheimer's GWAS, 3D genomics, and single-cell CRISPRi non-coding screen implicates causal variants in a microglial enhancer regulating TSPAN14.
Shannon Laub, Natalia M. Tulina, Matthew Hoffman…·Alessandra Chesi
Author
University of PennsylvaniaORCID 0000-0002-1997-4521Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Shannon Laub, Natalia M. Tulina, Matthew Hoffman…·Alessandra Chesi
Yuk Yee Leung, Pavel P. Kuksa, Luke Carter…·Li‐San Wang
The paper identifies EGFR as a potential therapeutic target in Alzheimer's disease by linking a risk variant to increased EGFR expression in brain cell types through genomic analysis and CRISPRi validation.
Ana G. Cristancho, Natalia M. Tulina, Lauren Anton…·Michal A. Elovitz
This study investigates age and sex-specific behavioral and molecular effects of prenatal inflammation in mice, finding male-specific anxiety increases in adults and sex-specific neurogenesis gene expression changes.