Molecular BiologybioRxivPreprint
Novel VCP activator reverses multisystem proteinopathy nuclear proteostasis defects and enhances TDP-43 aggregate clearance
Jessica M. Phan, Benjamin C. Creekmore, Aivi T. Nguyen…·Edward B. Lee
The paper identifies four novel VCP activators that enhance clearance of TDP-43 aggregates in cellular models of multisystem proteinopathy.
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