Benjamin C. Creekmore

This study shows that polyubiquitin repositioning affects tau filament structure in tauopathies, altering their seeding activity in mice.

This paper presents a method to image unfixed, never frozen human brain tissue using cryo-ET with xenon plasma FIB milling, revealing native ultrastructures like myelin and autophagy components.

The paper identifies novel VCP variants causing a childhood-onset neurodevelopmental disorder through exome sequencing and functional analysis.

The paper identifies four novel VCP activators that enhance clearance of TDP-43 aggregates in cellular models of multisystem proteinopathy.