Marco Alifano

This study uses single-cell RNA sequencing to show that radiotherapy induces pro-angiogenic signaling in human lung tissue, including upregulation of VEGFA and changes in capillary and macrophage populations.

This study shows mitochondrial metabolism, not glycolysis, is essential for CD8+ T cell migration in 3D tumor environments, and enhancing mitochondrial activity improves CAR T cell infiltration and tumor control.