Emmanuel Donnadieu

This paper develops an organotypic human tissue platform to assess CAR-T cell toxicity and shows it can predict tissue-specific toxicity profiles and identify factors influencing off-tumor effects.

The paper identifies monocyte interactions with CD8+ T cells during tumor regression, showing their role in promoting T-cell infiltration and anti-tumor immunity.

This study uses an in vivo CRISPR screen to identify genes that enhance CAR-T cell efficacy in a solid tumor model, finding that disrupting REGNASE-1, SOCS1, PTPN2, and P16/NK4A improves tumor eradication.

This study shows mitochondrial metabolism, not glycolysis, is essential for CD8+ T cell migration in 3D tumor environments, and enhancing mitochondrial activity improves CAR T cell infiltration and tumor control.

This study shows that blocking β-adrenergic receptor signaling enhances cancer vaccine efficacy by improving naive CD8+ T-cell priming, without affecting tumor-infiltrating CD8+ T-cell reactivity.