Hermann Schindelin

This study determines the structure of higher-order gephyrin oligomers using cryo-EM, revealing how its flexible linker regulates receptor binding and oligomerization.

The paper decodes the structural code governing CRA-CRA pairing in GID/CTLH-type E3 ligases and shows it can be reprogrammed through targeted perturbations.

This study characterizes the binding and modification requirements of 20 anti-Aβ antibodies across different Aβ forms, revealing aggregation-dependent sequence and modification selectivity.

This study shows that fluorination of inhibitors can tune protein dimerization affinity by altering enzyme-inhibitor interactions and dynamics.

This study identifies 7,8-dihydroxyflavone as a direct inhibitor of pyridoxal phosphatase, increasing PLP levels in mouse hippocampal neurons and validating PDXP as a druggable target.

This study shows artemisinins inhibit pyridoxal kinase, disrupting GABAergic signaling by reducing PLP production and affecting glutamic acid decarboxylase activity.

The paper introduces Haruspex, a convolutional neural network that automatically annotates Cryo-EM maps for protein secondary structures and RNA/DNA, achieving high recall and precision on test data.