Author
Institut für Pharmakologie und Toxikologie der BundeswehrORCID 0000-0002-2073-5683Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
3 papers
Recent·Most cited
Jesko Kaiser, Christoph G. W. Gertzen, Tamara Bernauer…·Holger Gohlke
This paper identifies novel ligands binding to MB327-PAM-1, a binding site for resensitizing nAChRs, including cycloguanil, which shows higher affinity and functional efficacy.
Tamara Bernauer, Valentin Nitsche, Jesko Kaiser…·Franz F. Paintner
This study synthesizes and evaluates new MB327 analogs as resensitizers for desensitized nicotinic acetylcholine receptors after nerve agent intoxication, identifying more potent compounds than MB327.
Valentin Nitsche, Georg C. Höfner, Jesko Kaiser…·Klaus T. Wanner
The paper establishes MS Binding Assays using UNC0642 as a reporter ligand to study the MB327 binding site of the nicotinic acetylcholine receptor, showing its effectiveness in both in vitro and in silico studies.