Vivek Appadurai

The paper shows genotype- and phenotype-based genetic instruments explain largely independent components of liability to psychiatric disorders, supported by theoretical analysis and simulations.

The paper shows that PHQ9 and CIDI-SF MDD symptoms have low to moderate genetic correlations, with distinct associations to dysphoria and symptom heterogeneity.

The paper introduces PA-FGRS, a method to estimate genetic liability from family records, and shows it improves MDD classification and GWAS power when combined with genotypes.

The paper evaluates how haplotype estimation and whole genome imputation accuracy vary with data integration protocols and phasing methods in a large psychiatric biobank dataset.

This study identifies genetic overlaps between psychiatric disorders, language ability, and creativity through a GWAS of school grades.

This paper improves genetic studies of MDD by integrating shallow and deep phenotypes, enhancing GWAS power and PRS accuracy while preserving specificity.

This study identifies 12,111 SNPs associated with height from 5.4 million individuals, explaining most common SNP-based heritability and showing ancestry-specific prediction accuracy.

The paper investigates genome-wide interactions between stressful life events and depression using a case-cohort study, identifying three genome-wide significant loci but lacking replication in an independent sample.

This study identifies genetic loci associated with suicide attempts and shows shared genetic architecture with psychiatric disorders and non-psychiatric risk factors.

This study identifies seven new genetic loci associated with febrile seizures, linking them to fever response and neuronal excitability genes, and suggests potential clinical applications of polygenic risk scores.

This study identifies a bidirectional association between autoimmune and mental disorders using Danish population data and finds HLA loci linked to autoimmune diseases but not mental disorders.

This study identifies four novel genetic loci associated with multiple psychiatric disorders, implicating fetal neurodevelopment as a key mediator of shared genetic risk.

This study identifies a fetal genome-wide association signal near pro-inflammatory cytokine genes on 2q13 linked to gestational duration and preterm/postterm birth.