Cancer BiologybioRxivPreprint
Unveiling the Power of PROTAC Valency: Navigating Cell Type-Specific Hook Effects
Arash Chitsazan, Frederik Eisele, Parisa Rabieifar…·Göran Dahl
The paper evaluates the impact of PROTAC valency on hook effects, showing that trivalent PROTACs do not eliminate the hook effect but may alter its dynamics.
DOI 10.1101/2024.06.12.598404