Nicolas Gautron

The paper introduces FASTOP, a genome-editing toolkit for yeast that enables rapid and reliable modification of transcriptionally active loci to construct multi-enzymatic pathways, achieving high production of naringenin.

The paper identifies MDR proteins as regulators of geissoschizine biosynthesis, enhancing activity and diversifying stereochemical outputs through ternary complex formation with GS and SGD.

This paper identifies and characterizes pachysiphine synthase genes in Tabernaemontana elegans using genome sequencing and computational analysis, enabling engineered yeast production of MIAs.