Per Kogner

This study identifies circadian gene network disruption in high-risk neuroblastoma across multiple biological contexts, showing it is a network-level alteration rather than a single-gene effect.

The paper identifies chromaffin-neuroblast plasticity as a mechanism linking paraganglioma and neuroblastoma through shared developmental states and hybrid cell populations.

This study shows ALK R1275Q mutation sustains an immature SCP-like cell state during sympathoadrenal commitment, increasing susceptibility to MYCN-driven neuroblastoma initiation.

This paper shows that HIF2α reduces MYCN protein levels and promotes a low-risk noradrenergic phenotype in neuroblastoma, suggesting HIF2 has tumor suppressor rather than oncogenic function.

This study shows METTL3 and MYCN cooperate to maintain undifferentiated neural crest cells in neuroblastoma, and METTL3 inhibition promotes differentiation and chemosensitivity.