Author

Perla Pucci

University of CambridgeORCID 0000-0003-1264-3487Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Suzanne Dawn TurneriD· 2 shared Akram MendeziD· 1 shared Anna DjosiD· 1 shared Aqsa Ali RehaniD· 1 shared Benedetto GrimaldiiD· 1 shared Bengt HallbergiD· 1 shared Charlotte Barrett· 1 shared Cheryl A. HawkesiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

Suzanne Dawn TurnerORCID

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3 papers

Recent·Most cited

Pharmacology & ToxicologyEpigenomicsPeer-reviewedJan 29, 2025

EZH2 inhibition enhances the activity of platinum chemotherapy in aggressive variant prostate cancer

Maryam Latarani, Perla Pucci, Mark Eccleston…·Francesco Crea

This study shows that EZH2 inhibition enhances platinum chemotherapy effectiveness in aggressive variant prostate cancer by reducing H3K27me3 and modulating DNA repair and apoptosis pathways.

6 citations

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologyThe EMBO JournalPeer-reviewedNov 11, 2024

METTL3/MYCN cooperation drives neural crest differentiation and provides therapeutic vulnerability in neuroblastoma

Ketan Thombare, Roshan Vaid, Perla Pucci…·Tanmoy Mondal

This study shows METTL3 and MYCN cooperate to maintain undifferentiated neural crest cells in neuroblastoma, and METTL3 inhibition promotes differentiation and chemosensitivity.

11 citations

humanDNA methylation

𝕏 PostBluesky

Cancer BiologybioRxivPreprintSep 5, 2024

FGFR2 promotes resistance to ALK tyrosine kinase inhibitors and its inhibition acts synergistically with lorlatinib in the treatment of ALK-expressing neuroblastoma

Perla Pucci, Charlotte Barrett, Ricky M. Trigg…·Suzanne Dawn Turner

This study identifies FGFR2 as a driver of resistance to lorlatinib in ALK-expressing neuroblastoma and shows that FGFR inhibition synergizes with lorlatinib to improve outcomes.

1 citation

humangenetic perturbation / CRISPR

𝕏 PostBluesky