Author

Joseph T.P. Yeeles

MRC Laboratory of Molecular BiologyORCID 0000-0002-2255-2119Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:DNA methylation· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1 Organism:yeast· 1

Frequent Co-Authors

Emma E FletcheriD· 2 shared Corella S. Casas-DelucchiiD· 1 shared Dilek GuneriiD· 1 shared Ella Taylor-CrossiD· 1 shared Federica RaguseoiD· 1 shared Gideon CosteriD· 1 shared Hiroyuki TakaiiD· 1 shared Isaac X R ChaniD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMolecular Biology

Emma E FletcherORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintMay 16, 2026

MCM10 targets CMG dimers via a conserved mechanism for synchronized helicase activation

Ella Taylor-Cross, Morgan L. Jones, Johann J. Roske…·Joseph T.P. Yeeles

The paper reveals a conserved mechanism by which MCM10 targets CMG dimers to synchronize helicase activation in eukaryotes through structural analysis of yeast and human complexes.

1 citation

yeasthuman

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Cell BiologyNaturePeer-reviewedFeb 28, 2024

CST--Polymeraseα-primase solves a second telomere end-replication problem

Hiroyuki Takai, Valentina Aria, Pamela Borges…·Titia de Lange

The paper identifies a second telomere end-replication problem caused by incomplete duplication of the C-rich strand, solved by CST-Polymeraseα-primase fill-in synthesis.

67 citationstop 1%

DNA methylationexperimental assay

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Molecular BiologyThe EMBO JournalPeer-reviewedOct 2, 2023

Replication-induced DNA secondary structures drive fork uncoupling and breakage

Sophie L. Williams, Corella S. Casas-Delucchi, Federica Raguseo…·Gideon Coster

This study shows that DNA secondary structures like G4s and iMs cause replication fork arrest and breakage, and that Pif1 helicase is required to resolve stalled forks.

52 citationstop 3%

humanDNA methylation

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