Josée Hébert

This study shows glucocorticoids eliminate AML leukemic stem cells by inducing differentiation and apoptosis, with mechanisms involving the glucocorticoid receptor and inflammatory signatures.

This study identifies compounds targeting human AML stem cells through a high-throughput screen and validates their efficacy using xenotransplantation and single-cell RNA sequencing.

EPCY ranks genes by predictive power using cross-validated classifiers and density estimation, outperforming DEG-based methods in selecting robust candidate genes.

This study identifies DEK::NUP214 as an XPO1-dependent transcriptional activator of leukemia genes, showing selective response to XPO1 inhibitors in t(6;9) AML cases.

The paper replicates a GWAS signal near HLA-DQA2 associated with AML risk using a disease-only cohort and external population-based controls, finding a stronger effect in patients with NPM1 mutations.

SPAT annotates proteins based on their likelihood to be at the cell surface using existing annotations, showing good performance on leukemia and public datasets.

This paper evaluates how dimensionality reduction techniques and gene signatures affect Cox-Proportional-Hazard models for AML prognosis using the Leucegene dataset.

The paper identifies Mubritinib as an ETC1 inhibitor effective against chemotherapy-resistant AML subtypes with OXPHOS hyperactivity and specific mutations.

This paper introduces km, a method for detecting targeted mutations in AML using unaligned RNA-Seq reads, showing it is fast, accurate, and limited by sequencing depth.