Zimu Li

This study characterizes the Rc-o319 S-protein's adaptation to R. cornutus ACE2 and identifies structural constraints limiting its ability to bind human ACE2.

The paper uses AI to identify convergent somatic hypermutation patterns in antibodies, enabling the discovery of variant-resilient broadly neutralizing antibodies from early-pandemic data.

The paper identifies public antibodies using VL6-57 light chains that target a conserved epitope on SARS-CoV-2 spike protein, showing how Omicron variants evolved to escape these antibodies.