Author

Wolfgang Fischle

King Abdullah University of Science and TechnologyORCID 0000-0002-2335-8932Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CRISPR screen· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Abdullah Fuaad Kadamany· 1 shared Amit Kumar SubudhiiD· 1 shared Anthony A. HolderiD· 1 shared Arnab PainiD· 1 shared Ashraf M. DadaiD· 1 shared Baolei YuaniD· 1 shared Chongwei BiiD· 1 shared Christian Frøkjær‐JenseniD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperGenomics

Abdullah Fuaad Kadamany

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintNov 13, 2025

HP1 dimerization drives the condensation and segregation of H3K9me-marked chromatin

Karthik Eswara, Jennifer I. Semple, Francesca Rivas-Cuestas…·Wolfgang Fischle

This study shows that HP1 dimerization drives H3K9me chromatin condensation and segregation, while LLPS stabilizes foci, and reveals a decoupling between heterochromatin and transcriptional regulation.

DOI 10.1101/2025.11.13.687974

C. elegansChIP-seq

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Molecular BiologyBMC BiologyPeer-reviewedApr 29, 2024

Modulation of the microhomology-mediated end joining pathway suppresses large deletions and enhances homology-directed repair following CRISPR-Cas9-induced DNA breaks

Baolei Yuan, Chongwei Bi, Yeteng Tian…·Mo Li

This study shows that modulating the MMEJ pathway components RPA and POLQ can reduce large deletions and enhance HDR after CRISPR-Cas9 editing.

21 citations

humanCRISPR screen

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GenomicsbioRxivPreprintMay 23, 2023

PfAP2-MRP DNA-binding protein is a master regulator of parasite pathogenesis during malaria parasite blood stages

Amit Kumar Subudhi, Judith L. Green, Rohit Satyam…·Arnab Pain

This study identifies PfAP2-MRP as a master regulator controlling parasite growth, chromatin structure, and var gene expression during malaria parasite blood stages.

6 citations

humanbulk RNA-seq

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