Pharmacology & ToxicologybioRxivPreprint
Estimating Organ-to-Plasma Ratios in physiologically based PK modeling: a simplified approach for early drug discovery
Fabio Broccatelli, Radha Ramakrishnan
This paper proposes a simplified method to estimate organ-to-plasma ratios in PBPK modeling using volume of distribution data, showing improved accuracy compared to in vitro-based approaches.
DOI 10.1101/2024.03.21.586167