Flavien Raynal

This study develops an in vitro 3D tumor spheroid model to target pro-tumoral macrophages with antibodies, showing effective killing even in spheroid centers.

The paper uses time-series RNA-Seq and gene regulatory network inference to study how CLL cells respond to immune signals in vitro, revealing dynamic regulatory mechanisms and patient-specific gene modules.

The paper investigates how chromatin organization and gene regulation change with evolutionary age during differentiation and cancer, identifying shifts in chromatin topology and gene interactions.

The paper investigates how enhancer-driven 3D chromatin domain folding regulates transcription in human mammary tumor cells following estradiol stimulation.

The paper investigates Drosophila insulators' role in 3D chromatin organization, finding that non-border preferential interactions occur before TADs and transcription.

This study identifies mH2A1.1's role in regulating RNA Polymerase II paused genes through distinct chromatin mechanisms in breast cancer cells.

The paper builds a Boolean model to simulate macrophage polarization in an in-vitro chronic lymphocytic leukaemia model, revealing the formation of tumour-associated macrophages.