Author

Mohan Maruthi Sena

Indian Institute of Technology MadrasORCID 0000-0002-2398-700XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:protein structure· 2 Approach:statistical model· 2 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Aayushi GuptaiD· 1 shared Anand Khedkar· 1 shared Ananya GanapathyiD· 1 shared Anirudh Ranganathan· 1 shared Bipin SinghiD· 1 shared M. Michael GromihaiD· 1 shared Mayilvahanan BoseiD· 1 shared Monalisa Chatterji· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperPharmacology & Toxicology

Aayushi GuptaORCID

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3 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintNov 2, 2026

Target Specific Conformational Flexibility and Electrostatic Complementarity Modulate LTNF10 Peptide Binding to Phospholipase A2 Variants from Snake Venoms

Aayushi Gupta, Mohan Maruthi Sena, Bipin Singh

This study investigates how charge and conformational changes in a peptide affect its binding to different snake venom PLA2 variants, revealing structural and electrostatic factors influencing affinity.

DOI 10.64898/2026.10.30.761852

protein structureprotein sequence

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Cancer BiologybioRxivPreprintSep 23, 2025

Integrative Microbiome Profiling of Colorectal Cancer Across South Asian and Western Cohorts Using Interpretable Machine Learning

Mohan Maruthi Sena, Ananya Ganapathy, Viveak Kumar…·Mayilvahanan Bose

This study uses machine learning to identify microbial biomarkers for early colorectal cancer detection across South Asian and Western cohorts, finding distinct microbial signatures associated with CRC.

DOI 10.1101/2025.09.23.677677

humanmetagenomics

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BiophysicsbioRxivPreprintDec 2, 2023

Mapping Structural Drivers of Insulin and its Analogs at the IGF-1 Receptor Using Molecular Dynamics and Free Energy Calculations

Mohan Maruthi Sena, Ramakrishnan C, M. Michael Gromiha…·Anirudh Ranganathan

This study uses molecular dynamics and free energy calculations to predict insulin analog potency at IGF-1R and identify structural drivers of activity.

DOI 10.1101/2023.12.02.569705

humanprotein structure

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