Author
Matthew Lyon
University of BristolORCID 0000-0002-2500-1013Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2020-2022 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 26 mutual co-author links7 papers
Recent·Most cited
- Genetic & Genomic MedicinemedRxivPreprint
Hypothesis-free detection of gene-interaction effects on biomarker concentration in UK Biobank using variance prioritisation
Matthew Lyon, Louise A C Millard, George Davey Smith…·Kate M. Tilling
The paper develops a variance prioritisation method to detect gene-interaction effects on blood biomarker concentrations using UK Biobank data, identifying novel gene-environment and gene-gene interactions.
6 citations - BioinformaticsEuropean Journal of EpidemiologyPeer-reviewed
A robust mean and variance test with application tohigh-dimensional phenotypes
James R Staley, Frank A. G. Windmeijer, Matthew J Suderman…·Kate M. Tilling
The paper introduces a robust statistical test for detecting associations with both mean and variability in high-dimensional phenotypes, applied to DNA methylation data.
14 citations - GeneticsbioRxivPreprint
Genetic effect modification of cis-acting C-reactive protein variants in cardiometabolic disease status
Jie Zheng, Haotian Tang, Matthew Lyon…·George Davey Smith
This study shows genetic associations of CRP variants with BMI differ between individuals with and without cardiometabolic diseases, suggesting BMI modifies these genetic effects.
4 citations - GeneticsGenome biologyPeer-reviewed
The variant call format provides efficient and robust storage of GWAS summary statistics
Matthew Lyon, Shea J. Andrews, Benjamin Elsworth…·Edoardo M. Marcora
The paper introduces GWAS-VCF, a variant call format for GWAS summary statistics, showing it is faster and more robust than tabular formats for data extraction and analysis.
262 citationstop 1% - BioinformaticsBioinformaticsPeer-reviewed
EpiGraphDB: a database and data mining platform for health data science
Yi Liu, Benjamin Elsworth, Pau Erola…·Tom R. Gaunt
EpiGraphDB is a graph database and analytical platform for health data science, demonstrating its utility through case studies on pleiotropy, drug targets, and causal inference.
60 citations - GeneticsbioRxivPreprint✦ In-depth digest
The MRC IEU OpenGWAS data infrastructure
Benjamin Elsworth, Matthew Lyon, Tessa Alexander…·Gibran Hemani
OpenGWAS serves 14582 harmonised, complete GWAS summary datasets (125.8 billion associations) via API, R/Python clients and GWAS-VCF downloads, with glue code for Mendelian randomization, colocalisation and fine-mapping.
940 citations