Warren W. Kretzschmar

The paper reports genotyping and population structure findings from the China Kadoorie Biobank, revealing relatedness, consanguinity, and population movement patterns.

ClusTrast improves de novo transcript isoform reconstruction by clustering contigs and merging assemblies, outperforming existing tools in recall and polymorphism detection.

This study identifies traits associated with polygenic risk for depression using UK Biobank data and finds causal links between depression risk and brain structure, as well as environmental interactions.

The paper examines how genetic and environmental factors influence DNA methylation at variably methylated regions in neonatal blood, finding that combined effects best explain methylation variability.

The paper applies polygenic risk scoring to a large family with bipolar and depressive disorders to study genetic risk patterns and anticipation.

This study presents a comprehensive catalog of genetic variation in Han Chinese using whole-genome sequencing, revealing population structure, admixture, and loci under local adaptation.

Genome-wide association meta-analysis of 130,664 major depression cases and 330,470 controls identifies 44 independent risk loci enriched in cortical neurons, conserved mammalian regions, splicing networks, and antidepressant targets.

This paper estimates narrow-sense heritability using identity-by-descent information in unrelated individuals and finds that IBD-based methods can capture rare variant contributions but are affected by stratification.